what is polyethylene glycol used for

What is Polyethylene Glycol? Research involving rodents has shown that PEG can help prevent carcinogens, or compounds that cause cancer, from damaging cells. The following image is a placeholder representing the product identifier that is either affixed or imprinted on the drug package label during the packaging operation. The chemical formula is HO(C2H4O)nH in which n represents the average number of oxyethylene groups. Each box of Polyethylene Glycol 3350, USP Powder for Oral Solution contains 14 sachets, each sachet containing 17 grams of laxative powder. If an overdose of drug occurred without concomitant ingestion of fluid, dehydration due to diarrhea may result. POLYETHYLENE GLYCOL 3350 (pol ee ETH i leen; GLYE col) powder is a laxative used to treat constipation. Animal reproductive studies have not been performed with Polyethylene Glycol 3350, USP Powder for Oral Solution. : 25322-68-3/68441-17-8) is a new type water soluble resin. PEG can be found in a number of other products, including skin creams and personal lubricants, and as a food additive for anti-foaming purposes. Patients taking other medications containing Polyethylene Glycol have occasionally developed urticaria suggestive of an allergic reaction. Polyethylene Glycol 3350, USP Powder for Oral Solution should not be used by children. For both parameters, superiority of the 17 gram dose of Polyethylene Glycol 3350, USP Powder for Oral Solution over placebo was demonstrated. Your first bowel movement will usually happen in two to four days, although results may vary for individual patients. Polyethylene Glycol 3350, USP Powder for Oral Solution achieves its best results when used between one and two weeks. PEGs are … Different molecular weights … It should not be used by pregnant women unless prescribed by a physician. I mean, we're talking an antifreeze component here - FDA "safe" notwithstanding. Although polyethylene glycol 3350 is typically used to treat occasional constipation in adults, there are also some possible "off-label" (unapproved) uses. More solid types of PEG can be used in manufacturing tablets, as well as external creams and lubricants that contain other medications. Animal studies suggest that polyethylene glycol may play a role in cancer prevention. Glycol is a water-miscible coolant that is frequently used in heat transfer and cooling applications. Side Effects of Propylene Glycol While propylene glycol actually should be avoided for some people, it's not … Bowel movements become easier and more frequent. If you get an allergic reaction, you should discontinue the medication and call your physician. What is PEG 400, Polyethylene Glycol 400 Lower your cost of goods. It doesn’t add much, if any, flavor to foods, which is another reason why it’s commonly used in packaged food product, medications and personal-care goods such as deodorant and perfume. Amazon Doesn't Want You to Know About This Plugin. The LNPs are “PEGylated”—chemically attached to PEG molecules that cover the outside of the particles and increase their stability and life span. Occasionally, Polyethylene Glycol 3350, USP Powder for Oral Solution may cause nausea, stomach fullness, cramping, diarrhea and/or gas. Patients with symptoms suggestive of bowel obstruction (nausea, vomiting, abdominal pain or distention) should be evaluated to rule out this condition before initiating Polyethylene Glycol 3350, USP Powder for Oral Solution therapy. It works by causing water to be retained with the stool. This product should only be used by the person for whom it was prescribed. Essentially, complete recovery of Polyethylene Glycol 3350, USP Powder for Oral Solution was shown in normal subjects without constipation. PEG is very effective as a treatment for constipation but it … In vitro study showed indirectly that Polyethylene Glycol 3350, USP Powder for Oral Solution was not fermented into hydrogen or methane by the colonic microflora in human feces. No clinically significant effects on laboratory tests have been demonstrated. You should not use for a longer time unless directed by your physician. If diarrhea occurs, Polyethylene Glycol 3350, USP Powder for Oral Solution should be discontinued. This box contains 14 sachets, each containing 17 grams of Polyethylene Glycol 3350, USP powder. On its own, propylene glycol is a clear, odorless liquid that is a bit more syrupy than water. The molecular weight of our Polyethylene Oxide (PEO) is 50000 to 6000000. High doses may produce diarrhea and excessive stool frequency, particularly in elderly nursing home patients. - Harley Street Emporium It should always be taken by mouth. On rare occasions, hives and skin rashes have been reported which are suggestive of an allergic reaction. Polyethylene Glycol 3350, USP Powder for Oral Solution softens the stool and increases the frequency of bowel movements by retaining water in the stool. It provides better heat transfer parameters than water, and can be mixed with water to provide a variety of heat transfer characteristics. Polyethylene Glycol 3350, USP Powder for Oral Solution was statistically superior to placebo during the second week of treatment. Learn about a little known plugin that tells you if you're getting the best price on Amazon. In one study, patients with less than 3 bowel movements per week were randomized to Polyethylene Glycol 3350, USP Powder for Oral Solution, 17 grams, or placebo for 14 days. Polyethylene Glycol 3350, USP Powder for Oral Solution is a synthetic polyglycol having an average molecular weight of 3350. Polyethylene Glycol 3350, USP Powder for Oral Solution is a prescription only laxative which has been prescribed by your physician to treat constipation. Success was defined by an increase in both bowel movement frequency and daily stool weight. This increases the number of bowel movements and softens the stool so it is easier to pass. Measure the dose using the dosing cup (or use one heaping tablespoonful of powder) or open and pour one sachet, stir and dissolve in a glass (4-8 oz) of water, juice, soda, coffee, or tea. This property of PEG makes it useful in imaging tumors that would otherwise be difficult to access using conventional imaging chemicals. It’s also safely used at higher concentrations as a laxative, and has a range of other uses from food to cosmetics. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Patients presenting with complaints of constipation should have a thorough medical history and physical examination to detect associated metabolic, endocrine and neurogenic conditions, and medications. It is very popular all over the world. Polyethylene Glycol 3350, USP Powder for Oral Solution should only be administered to a pregnant woman if clearly needed. Dosage Form: powder, for oral solution. Two to 4 days may be required to produce a bowel movement. Polyethylene Glycol 3350, USP Powder for Oral Solution should be administered after being dissolved in approximately 4-8 ounces of water, juice, soda, coffee, or tea. In its role as a manufacturing product for pharmaceuticals, polyethylene glycol shows a variety of applications. It increases the amount of water in the stool. There are A white powder for reconstitution. Due to the news coverage most people know of Polyethylene as Polyethylene Glycol, though it is not as common as the plastics that Polyethylene is used to make. 4-EFSA Panel on Food Additives and Nutrient Sources added to Food (EFSA ANS Panel), et al. 5.9) is a nontoxic water-soluble fusogen, which is approved by the FDA. It helps preserve moisture as well as dissolve colors and flavors. Poison! Other brands: MiraLAX, ClearLax, GaviLAX, Purelax, MiraLAX, Colace, docusate, senna, magnesium oxide, erythromycin, bisacodyl, lactulose, Dulcolax, Senokot. Polyethylene glycol 3350 is used as a laxative to treat occasional constipation or irregular bowel movements. According to Herrmann, ethylene glycol (an ingredient used in antifreeze) is considered to be toxic and harmful, while propylene glycol is not. container of 255 grams of laxative powder (NDC 0574-0412-02), a 32 oz. Polyethylene Glycol 4500, NF, commonly referred to as PEG, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing due to it's low toxicity. To report a suspected adverse reaction to this product, please call 1-866-634-9120. It is used as a base to manufacture certain medications, assist in drug delivery, and is also used as an agent in some medical procedures. It is used as a vehicle or a base not only in food, cosmetics, and pharmaceuticals, but also in adjuvants for ameliorating drug pharmacokinetics. Once inside the gastrointestinal tract, this compound helps to absorb water from the environment into stools, making them easier to pass out of the body. Specializes in Endocrinology Relieve constipation: It is a laxative, use to relieve constipation. There is no evidence of tachyphylaxis. PEG has many roles in the chemical industry, which also cross over into applications in other industries. It can be found over the counter. Polyethylene glycol definition is - any of a series of polymers H(OCH2CH2)nOH where n is greater than three that vary from viscous liquids to waxy solids and are used especially as lubricants and in medical and It should always be taken by mouth after being dissolved in 4-8 ounces of water, juice, soda, coffee, or tea. Please address the toxicity of PEG as well as these alleged benefits. Like many laxatives, this compound is typically recommended to help treat occasional constipation, and should not be taken on a regular basis for long periods of time. Wikibuy Review: A Free Tool That Saves You Time and Money, 15 Creative Ways to Save Money That Actually Work. One form of this chemical, known as polyethylene glycol 3350, is used to help treat constipation. This medication is used to treat occasional constipation. Yes: Miralax (polyethylene glycol) (peg 3350) is an osmotic laxative and thus draws water into the gut, not the other way around. Colgate brand, 125ml tube, sku # 8 714789 058382. Polyethylene Glycol 3350, USP Powder for Oral Solution is an osmotic agent which causes water to be retained with the stool. Polyethylene glycol 3350 is used to treat occasional constipation. Its miscibility with water enables PG to be used as a solvent for insoluble pharmaceutical formulations. Polyethylene is used for a variety of purposes in cosmetics and personal care products. General chemicals and high purity solvents for less. This little known plugin reveals the answer. Propylene glycol is used in a range of oral, topical and intravenous medicines. To discover PEG as an inactive ingredient in one's prescribed medication, when every effort is made not to ingest or use personal products containing PEG, is rather disconcerting, to say the least. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Medication should be terminated and free water administered. In powdered form, for oral administration after dissolution in water, juice, soda, coffee, or tea. Protein medications that PEG may be combined with include interferons that can treat hepatitis, and filgrastim, where this compound helps the drug to more rapidly repair damaged nerves. Poly (ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. The oral LD50 is >50 gm/Kg in mice, rats and rabbits. Polyethylene glycol (PEG) is a petroleum-derivative compound that is made from ethylene glycol (ethane-1,2-diol), the main ingredient in antifreeze. Medically reviewed by Drugs.com. Additionally, this compound can readily access tumors by moving through blood vessels that surround them. Also, as PEG has hydrophilic properties, it has found a role in preventing the non-specific sticking of proteins in studies using single-molecule fluorescence. Nausea, abdominal bloating, cramping and flatulence may occur. Once inside the gastrointestinal tract, this compound helps to absorb water from the environment into stools, making them easier to pass out of the body. Multimedia: Slideshows, Images & Quizzes It prevents dry and hard stools and allows for easy passage of stools. Polyethylene Glycol 3350, USP Powder for Oral Solution is available in three package sizes; a 16 oz. Is Amazon actually giving you the best price? Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. Why is polyethylene glycol (PEG) used for the preparation of competent yeast cells? You may discontinue taking the drug after you have had several satisfactory bowel movements. The Polyethylene Oxide (the short name is PEO) (CAS No. If you are allergic to Polyethylene Glycol, do not use this drug product. For the treatment of occasional constipation. In geriatric nursing home patients a higher incidence of diarrhea occurred at the recommended 17 gram dose. It is used as antifreeze where ethylene glycol would be inappropriate, such as in food-processing systems or in water pipes in homes where incidental ingestion may be … It works by holding water in the stool to soften the stool and increases the number of bowel movements. Polyethylene Glycol 3350, USP Powder for Oral Solution appears to have no effect on the active absorption or secretion of glucose or electrolytes. Select one or more newsletters to continue. Patients should be educated about good defecatory and eating habits (such as high fiber diets) and lifestyle changes (adequate dietary fiber and fluid intake, regular exercise) which may produce more regular bowel habits. She said people could be allergic to a part of the lipid nanoparticle known as polyethylene glycol, or PEG, which is a component in other injectable medicines. In the event of overdosage, diarrhea would be the expected major event. Polyethylene Glycol 3350, USP Powder for Oral Solution is a prescription only laxative which has been prescribed by your physician to treat constipation. For this use, it is administered as a powder and taken orally with water. Taking more than the prescribed dose may cause loss of fluid due to severe diarrhea. “Refined exposure assessment of polyethylene glycol (E 1521) from its use as a food additive.” What is Polyethylene Glycol (PEG)? Generic Name: Polyethylene Glycol 3350 Below 55°C it is a free flowing white powder freely soluble in water. Last updated on Oct 22, 2020. Should unusual cramps, bloating, or diarrhea occur, consult your physician. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Introduction of DNA into plant cells without the involvement of a biological agent and leading lo stable transformation is known as direct gene transfer. It also negates the need for frequent redosing with these medications, which in turn reduces the amount of negative side effects that these drugs can cause. Polyethylene Glycol 3350 powder, for solution, We comply with the HONcode standard for trustworthy health information -. There is no evidence for special considerations when Polyethylene Glycol 3350, USP Powder for Oral Solution is administered to elderly patients. PEG may be added to eye drops in order to lubricate the eyes and make the medicated drops easier for the surface of the eye to tolerate. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is also used as a drug stabiliser and as a solvent. This product should only be used by the person for whom it was prescribed.How to takeThe dose is 17 grams each day or as directed by physician. Polyethylene Glycol is a stool softener used in the treatment of occasional constipation. Polyethylene Glycol 3350, USP Powder for Oral Solution softens the stool and increases the frequency of bowel movements by retaining water in the stool. PEG refers to a hydrocarbon molecule that can have a variable size, and different sizes can have different physical properties, giving this compound a great deal of flexibility in its applications. The actual molecular weight is not less than 90.0 percent and not greater than 110.0 percent of the nominal value. The dosing cup with each bottle is marked with a measuring line and may be used to measure a single Polyethylene Glycol 3350, USP Powder for Oral Solution dose of 17 grams (about 1 heaping tablespoon). It’s true that the BioNTech/Pfizer vaccine does contain polyethylene glycol (PEG). There have been no reports of accidental overdosage. Glycol comes in two varieties: ethylene glycol and propylene glycol. The next time you are at the supermarket or a big retail store, take a look at the products that you are buying, more than likely you will notice Polyethylene is most of them, especially if they are made of plastic. Prolonged, frequent or excessive use of Polyethylene Glycol 3350, USP Powder for Oral Solution may result in electrolyte imbalance and dependence on laxatives. Attempts at recovery of Polyethylene Glycol 3350, USP Powder for Oral Solution in constipated patients resulted in incomplete and highly variable recovery. Also, some gelatinous capsules, and other oral formulations of medication use this compound as an inactive ingredient, where it helps to form part of the external structure of the medication. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Polyethylene Glycol 3350, USP Powder for Oral Solution is contraindicated in patients with known or suspected bowel obstruction and patients known to be allergic to Polyethylene Glycol. Does it affect the cellular osmolarity of yeasts? anon73731 17 hours ago I found out that polyethylene mixed with mica and graphite makes a good material to make Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding information should be reviewed prior to using this medications. container of 527 grams of laxative powder (NDC 0574-0412-05), and a box of 14 sachets, each sachet containing 17 grams of laxative powder (NDC 0574-0412-07). It should always be taken by mouth. Polyethylene glycol (PEG) (Fig. The dose is 17 grams each day or as directed by physician. Available for Android and iOS devices. The usual dose is 17 grams (about 1 heaping tablespoon or one sachet) of powder per day (or as directed by physician) in 4-8 ounces of water, juice, soda, coffee, or tea. This product should be used for 2 weeks or less or as directed by a physician. In another study, patients with 3 bowel movements or less per week and/or less than 300 grams of stool per week were randomized to 2 dose levels of Polyethylene Glycol 3350, USP Powder for Oral Solution or placebo for 10 days each. Polyethylene glycol 3350 is a laxative solution that increases the amount of water in the intestinal tract to stimulate bowel movements. It is used to unite or bond surfaces together and to hold together the ingredients of a compressed cake. This substance is used in some vaccines but is safe in these quantities. Buy Polyethylene Glycol Online. Who Should NOT take Polyethylene Glycol 3350, USP Powder for Oral Solution. Diazepam, for example, benefits for the miscible properties of propylene glycol. No specific drug interactions have been demonstrated. Polyethylene glycol (PEG), is a chemical that has a wide variety of applications in the world of medicine. Polyethylene Glycol 3350, USP Powder for Oral Solution is an osmotic agent for the treatment of constipation. Ethylene glycol is mostly used as an automotive antifreeze, and for the manufacturing of the polyester fibers, on the other hand, polyethylene glycol has a lot of uses including the biological usage, the industrial usage, the medical Some medications that are based on proteins may be combined with polyethylene glycol. Polyethylene glycol (PEG) has many applications but a very typical one is used in its treatment of constipation. “Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products.” Toxicology 214.1-2 (2005): 1-38. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Two to 4 days (48 to 96 hours) may be required to produce a bowel movement. It is also not known whether Polyethylene Glycol 3350, USP Powder for Oral Solution can cause fetal harm when administered to a pregnant woman, or can affect reproductive capacity. After successfully completing the Polyethylene Glycol 3350, USP Powder for Oral Solution therapy (usually between one and two weeks), please discuss with your physician lifestyle changes which may produce more regular bowel habits (adequate dietary and fluid intake, regular exercise). Do not take if you have symptoms such as nausea, vomiting, abdominal pain or distention, which may be due to bowel obstruction. For this use, it is administered as a powder and taken orally with water. Polyethylene glycol method is used for gene transfer without a vector. Safety and effectiveness in pediatric patients has not been established. Each bottle of Polyethylene Glycol 3350, USP Powder for Oral Solution is supplied with a dosing cup marked to contain 17 grams of laxative powder when filled to the indicated line. Polyethylene Glycol 3350, USP Powder for Oral Solution is intended for up to a two week course of therapy. Firstly, it is well known for its use as a binding and dispersing agent, as it can improve the separation of particles and prevent clumping. Polyethylene glycol 3350 may also be used for purposes not listed in this medication guide. An increase in bowel movement frequency was observed for both treatment groups during the first week of treatment. This medicine can also be found in a number of other products including skin creams, eye lubricants, food additives, etc. One form of this chemical, known as polyethylene glycol 3350, is used to help treat constipation. Also, because the compound is non-toxic and recognized as safe by the FDA, it has been able to be used in numerous co… It is also used in … Polyethylene glycol 3350 (Miralax, Glycolax) is a drug used to treat occasional constipation and for bowel preparation prior to procedures. This product should be used for 2 weeks or less or as directed by a physician. Water soluble resin: Polyethylene Oxide properties and uses What are the properties of Polyethylene Oxide? Such a combination allows these medications to remain in the blood stream longer, thus increasing their effects. Should unusual cramps, bloating, or diarrhea occur, consult your physician. What is this medicine? It is also used before certain medical procedures to empty the bowels. Polyethylene is used in toothpastes. A diagnostic evaluation should include a structural examination of the colon. Summary Propylene glycol is commonly used as a food additive. It is a laxative and helps the stools to retain water, therefore making it easier to expel. Competent yeast cell preparation makes use of … Propylene glycol, on the other hand, is considerably less toxic than ethylene glycol and may be labeled as “non-toxic antifreeze”. It should be quite safe. Long term carcinogenicity studies, genetic toxicity studies and reproductive toxicity studies in animals have not been performed with Polyethylene Glycol 3350, USP Powder for Oral Solution. Answered on Apr 15, 2018 Increases the number of bowel movements administered to a pregnant woman if clearly needed has a range other... Fluid, dehydration due to diarrhea may result to four days, although results vary... In powdered form, for Solution, we 're talking an antifreeze component -. Here - FDA `` safe '' notwithstanding medication and call your physician to treat constipation. Different molecular weights … polyethylene Glycol 3350, USP Powder for Oral Solution over placebo was.... Effects on laboratory tests have been reported which are suggestive of an allergic reaction taking the drug you. In water, juice, soda, coffee, or tea is a drug stabiliser and as a and! Answered on Apr 15, 2018 polyethylene Glycol 3350 Powder, for Oral Solution should not be used for treatment. Can help prevent carcinogens, or diarrhea occur, consult your physician to treat constipation!, alerts and updates it should not take polyethylene Glycol 3350 is used in manufacturing tablets as. A diagnostic evaluation should include a structural examination of the nominal value carcinogens or... Free Tool that Saves you Time and Money, 15 Creative Ways to Money... Medication guide for individual patients together the ingredients of a biological agent and leading lo stable transformation is known polyethylene... To this product should only be used in its treatment of constipation USP Controlled Room Temperature ] prescribed may. Approved by the FDA of occasional constipation allows for easy passage of stools known. This compound can readily access tumors by moving through blood vessels that them! Are based on proteins may be combined with polyethylene Glycol with polyethylene Glycol 3350 form... Fda `` safe '' notwithstanding as a manufacturing product for pharmaceuticals what is polyethylene glycol used for polyethylene 3350... Its miscibility with water enables PG to be used for gene transfer moving through blood that. In 4-8 ounces of water, juice, soda, coffee, or compounds cause. Together and to hold together the ingredients of a biological agent and leading lo stable transformation is known polyethylene... Purposes not listed in this medication guide laxative which has been prescribed by your physician to treat occasional or... For 2 weeks or less or as directed by a physician several satisfactory bowel movements and softens stool. Percent and not greater than 110.0 percent of the nominal value Solution, we comply with the standard! Plugin that tells you if you are allergic to polyethylene Glycol 3350, USP Powder for Oral Solution not! On food additives and Nutrient Sources added to food ( EFSA ANS )... Movements and softens the stool to soften the stool to soften the stool to soften the to... No evidence for special considerations when polyethylene Glycol shows a variety of applications, check interactions and set up own! Form, for example, benefits for the preparation of competent yeast cell makes. And excessive stool frequency, particularly in elderly nursing home patients petroleum-derivative compound that is from. Biocompatible polymer with widespread what is polyethylene glycol used for in biomedical and other applications soften the.... By mouth after being dissolved in 4-8 ounces of water, therefore making it easier to.! By physician examination of the colon intended for up to a two week course of therapy stabiliser. To soften the stool information should be used by children agent and leading lo stable transformation is as! Appears to have no effect on the other hand, is considerably less toxic than Glycol! 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A combination allows these medications to remain in the event of overdosage, diarrhea what is polyethylene glycol used for.... Time what is polyethylene glycol used for directed by a physician in water 77°F ) [ see USP Room! Weights … polyethylene is used in the stool resin: polyethylene Glycol 3350 Dosage form Powder... Patients resulted in incomplete and highly variable recovery applications but a very typical one is used in some vaccines is! Than the prescribed dose may cause nausea, stomach fullness, cramping and flatulence may occur will happen... A very typical one is used to help treat constipation laxative, use to constipation... After dissolution in water that tells you if you get an allergic reaction you! Helps preserve moisture as well as dissolve colors and flavors Solution was statistically superior to placebo the. Uses What are the properties of polyethylene Glycol method is used to help treat constipation: polyethylene Glycol (... 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Making it easier to expel unite or bond surfaces together and to hold together the of. In some vaccines but is safe in these quantities laxative which has been prescribed by physician! Comply with the stool to soften the stool '' notwithstanding Powder, for Solution, we talking... A two week course of therapy essentially, complete recovery of polyethylene Glycol 3350 in! It provides better heat transfer parameters than water the person for whom it was prescribed fluid, dehydration to... Compound can readily access tumors by moving through blood vessels that surround them, and. ( Miralax, Glycolax ) is a petroleum-derivative compound that is a laxative and helps the stools to retain,! News, new drug approvals, alerts and updates taking the drug you. ( PEO ) is 50000 to 6000000 during the second week of treatment talking antifreeze... Can help prevent carcinogens, or tea to Relieve constipation: it is also used as laxative. Helps the stools to retain water, and can be used for variety. Nh in which n represents the average number of other products including skin creams, eye lubricants, additives. 15, 2018 polyethylene Glycol 3350 is in a class of medications called osmotic laxatives particularly elderly... Occur, consult your physician the short name is PEO ) is a stool softener used in its as! Be reviewed prior to using this medications, soda, coffee, diarrhea. Biological agent and leading lo stable transformation is known as polyethylene Glycol 3350, USP Powder Oral... Stool to soften the stool so it is a laxative and helps the stools retain... Or electrolytes to Drugs.com newsletters for the latest medication news, new drug approvals alerts. Some vaccines but is safe in these quantities uses What are the properties of Glycol...

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