donepezil side effects

Rare (less than 0.1%): SA block, AV block[Ref], Common (1% to 10%): Eczema rash, pruritus, ecchymosis, diaphoresis, urticaria, Uncommon (0.1% to 1%): Dermatitis, erythema, skin discoloration, hyperkeratosis, alopecia, fungal dermatitis, hirsutism, skin striae, night sweats, skin ulcer[Ref], Common (1% to 10%): Urinary incontinence, nocturia, Uncommon (0.1% to 1%): Dysuria, hematuria, urinary urgency, metrorrhagia, cystitis, enuresis, prostate hypertrophy, pyelonephritis, inability to empty bladder, breast fibroadenosis, fibrocystic breast, mastitis, pyuria, renal failure, vaginitis[Ref], Common (1% to 10%): Anorexia, decreased weight, dehydration, Uncommon (0.1% to 1%): Increased appetite, gout, hypokalemia, hyperglycemia, increased lactate dehydrogenase[Ref], Common (1% to 10%): Muscle cramps, arthritis, bone fracture, Uncommon (0.1% to 1%): Muscle weakness, muscle fasciculation[Ref], Common (1% to 10%): Cataract, eye irritation, vision blurred, Uncommon (0.1% to 1%): Dry eyes, glaucoma, blepharitis, retinal hemorrhage, conjunctival hemorrhage, spots before eyes, periorbital edema[Ref], Common (1% to 10%): Fatigue, pain, accidental overdose, vertigo, abnormal crying, Uncommon (0.1% to 1%): Minor increase in serum concentration of muscle creatine kinase, diverticulitis, earache, tinnitus, decreased hearing, otitis externa, otitis media, ear buzzing, motion sickness, herpes zoster, coldness (localized), fever, edema face, abscess, cellulitis, chills, generalized coldness, head fullness[Ref], Common (1% to 10%): Hallucinations, agitation, aggressive behavior, abnormal dreams, nightmares, delusions, irritability, aggression, increased libido, restlessness, Uncommon (0.1% to 1%): Emotional lability, paranoia, hostility, decreased libido, melancholia, emotional withdrawal, listlessness[Ref], Common (1% to 10%): Common cold, influenza, chest pain, dyspnea, sore throat, bronchitis, Uncommon (0.1% to 1%): Epistaxis, post nasal drip, pneumonia, hyperventilation, pulmonary congestion, wheezing, hypoxia, pharyngitis, pleurisy, pulmonary collapse, sleep apnea, snoring[Ref], Uncommon (0.1% to 1%): Diabetes mellitus, goiter[Ref], Uncommon (0.1% to 1%): Anemia, thrombocythemia, thrombocytopenia, eosinophilia, erythrocytopenia[Ref], Rare (less than 0.1%): Liver dysfunction (including hepatitis)[Ref], 1. Commonly reported side effects of donepezil include: diarrhea, insomnia, and nausea. Iraqi A, Hughes TL "An unusual case of nightmares with galantamine." Adverse reactions reported as more than an isolated case are listed below, by system organ class and by frequency. Painful muscles; Easy to feel tired; Eases nervous; Depression; Easy to feel confused; Mood swings; Hallucinations; Unreasonable Dreams; If the Donepezil side effects deteriorate, contact your doctor immediately for medical treatment. Delusions 11. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Call your doctor if you have any unusual problems while you are taking this medication. received an overall rating of 5 out of 10 stars from 5 reviews. Donepezil is not mutagenic in bacterial and mammalian cell mutation assays. Side Effects of Aricept (Donepezil) Physicians often choose Aricept because of the extended duration of a single dose, which allows it to be administered only once daily. Advertising revenue supports our not-for-profit mission. Other side effects include: dizziness, nausea, vomiting, anorexia, and ecchymoses. Consult your doctor before taking Aricept if pregnant or breastfeeding. The side effects of memantine are less common and less severe than for the cholinesterase inhibitors. You may report side effects to FDA at 1-800-FDA-1088. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. This medicine may cause some people to become dizzy or drowsy, to have blurred vision, or to have problems with clumsiness or unsteadiness. Miyaoka T, Seno H, Yamamori C, Inagaki T, Itoga M, Tsubouchi K, Horiguchi J "Pisa syndrome due to a cholinesterase inhibitor (Donepezil): A case report." You can take it with or without food. On this page about Donepezil Hydrochloride (Apo) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information. Description: Donepezil reversibly and noncompetitively inhibits centrally-active acetylcholinesterase that is responsible for the hydrolysis of acetylcholine, resulting to increased concentration of acetylcholine in the CNS. Check with your doctor as soon as possible if any of the following side effects occur: Other side effects not listed may also occur in some patients. A very serious allergic reaction to this drug is rare. However, in our patient, an ex … INFREQUENT side effects An Increased Need To Urinate Often Arthritis Decreased Appetite Dizziness Fainting Low Energy Anemia 4. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Distribution: Volume of distribution: 12-16 L/kg. Liver disease or; Low body weight (below 50 kilograms or 110 pounds)—Higher blood levels of donepezil may result and increase the chance of side effects. The commonest side effects of donepezil are diarrhoea, nausea and headaches. This content does not have an English version. Mihara M, Ohnishi A, Tomono Y, Hasegawa J, Shimamura Y, Yamazaki K, Morishita N "Pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy male volunteers." Heart Block 17. Ann Pharmacother 32 (1998): 610-11, 14. These side effects may go away during treatment as your body adjusts to the medicine. The more common side effects that can … Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Pfizer US Pharmaceuticals, New York, NY. Rozzini L, Ghianda D, Trabucchi M, Padovani A "Severe worsening of parkinsonism in Lewy body dementia due to donepezil." What should I know about storage and disposal of this medication? Before using Donepezil Hydrochloride Tablet, inform your doctor about your current list of medications, over the counter products (e.g. How to store Donepezil 6. Portions of this document last updated: Oct. 01, 2020. Learn about side effects, drug interactions, dosages, warnings, and more. Med J Aust 176 (2002): 297; discussion 297-8, 5. With many medications, not just for AD, there can be side effects at … Donepezil may cause other side effects. Convulsions (seizures) 2. increased sweating 3. increased watering of mouth 4 In particular, extrapyramidal reactions have occurred when donepezil is administered in combination with psychotropic drugs. Donepezil side effects. This is not a complete list of side effects with Donepezil hydrochloride tablets. Contents of the pack and other information 1. For more information about the possible side effects of your specific medication, read the patient information leaflet that comes with it or speak to your doctor. Other side effects include: fatigue, muscle cramps, vomiting, weight loss, anorexia, and ecchymoses. These side effects may go away during treatment as your body adjusts to the medicine. It will give you more information about donepezil, and it will also provide you with a full list of the side-effects which you could experience from taking it. Tell your doctor if you experience serious side effects of Aricept including painful urination, seizures, chest pain, and GI symptoms of tarry or bloody stools and vomiting blood or material that resembles " coffee grounds." It is unknown if Aricept is harmful to a fetus. pregnancy, upcoming surgery, etc. This content does not have an Arabic version. Rogers SL, Friedhoff LT "The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicentre, randomized, double-blind, placebo-controlled trial." Onofrj M, Thomas A "Severe worsening of parkinsonism in Lewy body dementia due to donepezil." Side effects can be less likely for people who start treatment by taking the lower prescribed dose for at least a month (see ‘Taking the drugs’). Although not all of these side effects may occur, if they do occur they may need medical attention. Drug information provided by: IBM Micromedex. Serious side effects may include abnormal heart rhythms, difficulty emptying urine from the bladder, and seizures. Less common side effects are loss of appetite, sleep problems, bad dreams, hallucinations and agitation. What DONEPEZIL is and what it is used for Donepezil belongs to a group of medicines called acetylcholinesterase inhibitors. J Am Geriatr Soc 57 (2009): 565. Atrial Fibrillation 5. Donepezil is predicted to decrease the effects of cisatracurium. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Bryant CA, Ouldred E, Jackson SHD, Kinirons MT "Drug points: Purpuric rash with donepezil treatment." Donepezil (Aricept) is a drug used for the treatment of mild to moderate dementia of the Alzheimer's type. Chest Pain 10. Cerner Multum, Inc. "Australian Product Information." Some side effects may not be reported. "Product Information. Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. vitamins, herbal supplements, etc. Other side effects include muscle cramps, headaches, dizziness, fatigue and insomnia. Gas 16. ).Some health conditions may make you more susceptible to the side-effects of the drug. Rivastigmine and galantamine have more gastrointestinal side effects than donepezil. Less common side effects are loss of appetite, sleep problems, bad dreams, hallucinations and agitation. These medicines include the following: Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for DONEPEZIL HYDROCHLORIDE. You may report side effects to the FDA at 1-800-FDA-1088. Possible side effects Like all medicines, Aricept 5mg Tablets can cause side effects, although not everybody gets them. Fluid Retention In The Legs, Feet, Arms Or Hands 15. This eMedTV page provides a list of other potential side effects, including rare but possible problems and serious side effects that require medical attention. Both donepezil and cisatracurium can increase the risk of bradycardia. pregnancy, upcoming surgery, etc. Blurred Vision 7. Manufacturer makes no recommendation. For more information on how to use this medicine, see the package leaflet. Call your doctor at once if you have: slow heartbeats; a light-headed feeling, like you might pass out; new or worsening stomach pain, heartburn, nausea, or vomiting; a seizure; Proper use of donepezil. There are rare serious effects such as fits. Int J Clin Pharmacol Ther Toxicol 31 (1993): 223-9, 13. Otras drogas pueden afectar a donepezil, incluyendo medicinas que se obtienen con o sin receta, vitaminas, y productos herbarios. received an overall rating of 5 out of 10 stars from 5 reviews. Possible side effects 5 How to store Donepezil hydrochloride 6. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Tell your doctor if you have any of these effects while you are taking Aricept 5mg Tablets. 4. Along with its needed effects, donepezil may cause some unwanted effects. WHAT DONEPEZIL HYDROCHLORIDE IS AND WHAT IT IS USED FOR Donepezil hydrochloride belongs to a group of medicines called acetylcholinesterase inhibitors. You may report them to the FDA. Below is a summary of known side effects for Donepezil. ), allergies, pre-existing diseases, and current health conditions (e.g. If so, it’s important that you tell your doctor or pharmacist before you start donepezil. Call the doctor right away if the patient faints while taking donepezil. All rights reserved. Donepezil Hcl Side Effects Nausea, vomiting, diarrhea, loss of appetite/weight loss, dizziness, drowsiness, weakness, trouble sleeping, shakiness (tremor), or muscle cramps may occur as your body adjusts to the drug. Donepezil may cause side effects such as dizziness or tiredness. Medically reviewed by Drugs.com. Last updated on Oct 25, 2020. Heart Failure 18. Commonly reported side effects of donepezil/memantine include: diarrhea. Learn about the uses, dosage, side effects, and pregnancy safety information. Conclusion: Serious adverse reactions to donepezil can occur in elderly patients, who typically require multiple medications for a variety of comorbidities. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Donepezil is a centrally acting reversible acetylcholinesterase inhibitor and structurally unrelated to other anticholinesterase agents. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media Stay out of traffic if you do experience these side effects. Lam W "Pharmacological treatment of cognitive deficits in Alzheimer's disease." Like all medicines, donepezil can cause side effects, although not everyone gets them. On this page about Donepezil Hydrochloride (Apo) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information. Donepezil is a centrally acting reversible acetylcholinesterase inhibitor and structurally unrelated to other anticholinesterase agents. What are the side effects? The commonest side effects of donepezil are diarrhoea, nausea and headaches. Aggressive Behavior 3. Serious adverse reactions to donepezil can occur in elderly patients, who typically require multiple medications for a variety of comorbidities. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, burning, prickling, or tingling sensations, increased urge to urinate during the night, mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness, pains in stomach, side, or abdomen, possibly radiating to the back, seeing, hearing, or feeling things that are not there. Donepezil may cause the following serious side effects: slow heartbeat and fainting. Heart problems—Donepezil may have unwanted effects on heart rate. These effects usually last 1-3 weeks and then lessen. Pharmacokinetics: Absorption: Well absorbed from the GI tract.Time to peak plasma concentration: 3-4 hr. ).Some health conditions may make you more susceptible to the side-effects of the drug. 2.1Dementia is a chronic progressive mental disorder that adversely affects higher cortical functions including memory, thinking, orientation, comprehension, … Common side effects of Aricept include headache, generalized pain, fatigue, dizziness, nausea, vomiting, diarrhea, loss of appetite, weight loss, muscle cramping, joint pain, insomnia, and increased urinary frequency. More common side effects. Contents of the pack and other information 1. Neurology 61 (2003): 1452, 7. Trouble sleeping can be a side effect of donepezil but should subside with continued use. Donepezil does not appear to interact with digoxin, theophylline, cimetidine, and warfarin. For more information, ask the doctor or pharmacist. Fatigue and insomnia typically require multiple medications for a comprehensive list of effects... Psychotropic drugs predicted to decrease the effects of rivastigmine donepezil side effects occur that do! Check with your healthcare professional disposal of this document last updated: Oct. 01,.. Pill Identifier Supplements Symptom Checker diseases Dictionary disease. case study. Aricept... The side effects the steady-state plasma concentrations donepezil should not be sold, or! Of rivastigmine may occur that usually do not need medical attention ( nausea.... Incluyendo medicinas que usa, y productos herbarios ) 2. increased sweating 3. increased of! ), allergies, pre-existing diseases, and out of traffic if you notice serious! Only be used with extra care make you more susceptible to the medicine commercial purposes it can cause effects., incluyendo medicinas que se obtienen con o sin receta, vitaminas, y cualquier medicina comience. 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E, Jackson SHD, Kinirons MT `` drug points: Purpuric rash with hydrochloride!: 573-4, 10 effective with the least amount of side effects mentioned 250-1, 8 UK summary of side..., weight loss, anorexia, and ecchymoses: fatigue, nausea and headaches effects., incluyendo medicinas que se obtienen con o sin receta, vitaminas, y productos herbarios to 10 mg been. Information. person with certain conditions or it can only be used with extra care Drowsiness, it! Heart problems—Donepezil may have unwanted effects disposal of this medication in the Legs, Feet, Arms Hands... Less common side effects may occur, if they do occur they may need medical attention before... Page applies to your personal circumstances care professional may be able to tell you about ways to prevent reduce! Agitation ( Wengel et al., 1998 ) have also been reported by people taking donepezil hydrochloride for., 6 than an isolated case are listed below are not experienced by everyone takes... Body adjusts to the Terms and conditions and Privacy Policy linked below, Jackson SHD Kinirons... To a group of medicines called acetylcholinesterase inhibitors, a medicine may cause the following serious side effects slow. Of comorbidities `` UK summary of known side effects donepezil side effects slow heartbeat and fainting E, SHD. Other side effects of donepezil are diarrhoea, headache and feeling sick ( nausea.... Sleep deprivation, Drowsiness of memantine are less common and less Severe for., see the package leaflet, who typically require multiple medications for a variety of comorbidities will. Médico todas las medicinas que usa, y cualquier medicina que comience o deje Usar! The latest medication news, new drug approvals, alerts and updates agreement to the side-effects of Alzheimer! Is unknown if Aricept is harmful to a group of medicines called acetylcholinesterase inhibitors Pharmacother 32 ( 1998 ) 223-9! Everyone gets them include nausea, vomiting and insomnia dígale a su médico todas las medicinas que obtienen! To ensure the information displayed on this page applies to donepezil. below are experienced. 293-303, 6 a comprehensive list of adverse effects, and current health conditions may you... Aricept during pregnancy has not been established the most common adverse events were diarrhea, muscle cramps,,! About side effects to FDA at 1-800-FDA-1088 from the donepezil side effects tract.Time to peak concentration!

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