(2) M.O. Figure 5 shows a representative Raman spectrum of the decomposition products formed from gasifying formic acid. Raman is a proven PAT for small molecule manufacturing and bioprocessing. Bioanal. DOI: 10.1039/C4AN00913D. In situ process Raman spectroscopy makes it possible to continuously monitor and identify gasification products such as H2, CO2, and CO in real-time. The Analyst 2015, 140 (3) , 854-859. This article reviews two industrial applications that have successfully used Raman spectroscopy as a PAT tool: The first industrial application is the manufacture and sampling of highly sensitive and reactive trialkyl aluminum compounds. 400, 2439–2447 (2011). It is based on inline UV-Vis, NIR, and Raman spectroscopy. • The standard procedure for method development is collecting inline Raman spectra at regular intervals with accurate time and date stamps. Pinkard, D.J. The utility of Raman for in-line, real-time process monitoring and control is demonstrated for content uniformity. The first example is the manufacture of organometallic compounds, such as trialkyl aluminum compounds, that are pyrophoric and dangerous to sample. 3b), to monitor the API concentration of the melt before it is extruded out through the die. Organometallic compounds like TMA constitute an extensive group of substances that have played a significant role in chemistry development. Given the ease of use, simplicity of data analysis, first principles compositional information, and versatility, Raman spectroscopy is an excellent tool for industrial process analysis and control. An example is trimethyl aluminum (TMA), a highly sensitive and reactive chemical compound. Our technology is fitted to the existing manufacturing facilities, boosting their productivity and quality. An alternative methodology is to extract one pure sample from the plant and “spike” it with known impurities to create a sample set, consisting of 18 samples specified by a design of experiments (DoE) approach. The spectral data were preprocessed using a first derivative and standard normal variate (SNV) treatment to correct for additive and multiplicative baseline effects and to enhance resolution. The November 2020 issue of Spectroscopy is available here. In this example, the measurement of organometallic purity was performed with process Raman spectroscopy. This article focuses on two examples of Raman’s safety and time benefits in process control. Taking a Raman measurement is as simple as shining a laser onto a sample. This is known as “process Raman spectroscopy.”. The ability to install your Raman spectroscopy system at the point of need is essential in these applications. What is the optimal way to manage process variability? As a result, process Raman spectroscopy has become an established PAT tool. Med, June 2, 2020. Outside the laboratory, Raman spectroscopy has found a home in manufacturing and quality analysis. Hazardous compound sampling and the transformation of organic waste into alternate fuel technology share one common factor: Both are more efficient when continuously monitored with a Raman spectrometer. At ColVisTec, we provide inline spectroscopy process control in extruders for pharmaceutical, chemical, coating, polymer and plastic extrusion via inline UV-Vis, NIR, Raman spectroscopy solutions. Timothy M. James, Simone Rupp, Helmut H. Telle. Furthermore, selecting the appropriate equipment is of the utmost importance when taking Raman spectroscopy out of a laboratory setting. Optical spectroscopy is today a very important method for online process monitoring and optimization. It offers a GMP user-friendly and easily deployed Process Analytical Technology (PAT) solution. such as a smartphone. 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